The PLUGS Podcast aims to empower healthcare providers, clinical laboratories, insurance plans, and patients by enhancing lab stewardship. Laboratory stewardship has five key improvement goals: 1) enhanced access to testing, 2) appropriate and accurate test ordering, 3) timely retrieval of test results, 4) correct result interpretation, and 5) financial alignment between patients, labs and payers. Financial alignment means that patients are protected from financial toxicity, labs are paid fairly, and insurance companies do not pay for wasteful test practices. Through insightful discussions, expert guidance, and valuable resources, the PLUGS Podcast is dedicated to supporting all stakeholders in navigating the complexities of clinical lab stewardship, ultimately promoting both better patient outcomes and financial security.